mRNA | Unstimulated | Stimulated | Unstimulated versus stimulated p-value | |||||
IRIS | Non-IRIS | p-value | IRIS | Non-IRIS | p-value | IRIS | non-IRIS | |
IL-1β | 6.4 (-1.3–7.8) | 6.7 (4.0–8.6) | 0.202 | -2.7 (-3.6–1.7) | -0.6 (-1.9–0.2) | <0.001 | <0.001 | <0.001 |
IL-2 | 11.5 (9.0–12.9) | 12.7 (12.2–13.7) | 0.014 | 8.3 (7.5–9.4) | 10.0 (7.0–12.7) | 0.129 | <0.001 | <0.001 |
IL-4 | 15.5 (14.9–16.7) | 16.1 (15.3–17.1) | 0.409 | 14.4 (14.1–15.8) | 15.4 (14.0–16.6) | 0.382 | 0.001 | 0.004 |
IL-5 | 20.2 (19.3–20.6) | 18.9 (18.0–20.0) | 0.003 | 12.1 (11.4–14.7) | 17.0 (13.9–20.1) | 0.001 | <0.001 | 0.13 |
IL-6 | 12.0 (4.0–13.8) | 12.4 (9.7–13.9) | 0.78 | 1.3 (0.3–3.7) | 4.6 (3.1–5.9) | <0.001 | <0.001 | <0.001 |
IL-8 | 3.0 (-0.2–3.8) | 2.6 (0.4–5.1) | 0.48 | -3.7 (-4.6–2.1) | -1.5 (-2.8–1.6) | 0.006 | <0.001 | 0.002 |
IL-10 | 6.9 (5.1–8.1) | 6.9 (6.0–7.1) | 0.74 | 4.9 (3.1–6.4) | 6.8 (5.9–8.5) | <0.001 | <0.001 | 1.0 |
IL-12p40 | 16.2 (12.1–17.5) | 16.9 (13.9–18.1) | 0.20 | 8.1 (6.5–9.4) | 10.0 (7.8–13.3) | 0.005 | <0.001 | <0.001 |
IL-13 | 17.6 (13.5–10.3) | 17.6 (14.8–18.4) | 0.61 | 8.8 (7.9–10.0) | 11.0 (9.4–13.7) | 0.002 | <0.001 | <0.001 |
IL-15 | 9.6 (8.6–10.5) | 10.6 (10.1–11.4) | 0.005 | 8.4 (7.9–8.7) | 8.6 (8.0–9.6) | 0.14 | 0.004 | <0.001 |
IL-17A | 18.3 (16.3–19.5) | 18.2 (17.7–19.4) | 0.698 | 12.7 (11.5–14.1) | 13.9 (12.8–15.3) | 0.048 | <0.001 | <0.001 |
IL-18 | 9.9 (9.2–10.4) | 10.5 (9.0–12.6) | 0.14 | 9.9 (8.9–10.7) | 9.6 (8.6–11.4) | 0.85 | 0.45 | 0.36 |
IFN−γ | 9.4 (6.0–10.6) | 9.6 (8.6–10.7) | 0.259 | 3.3 (1.8–5.1) | 6.8 (4.3–8.1) | 0.002 | <0.001 | <0.001 |
GM-CSF | 11.8 (8.6–14.3) | 13.6 (10.8–15.0) | 0.382 | 2.8 (-0.9–3.7) | 5.0 (3.9–6.8) | <0.001 | <0.001 | <0.001 |
TGF-β | 4.7 (4.4–5.4) | 4.5 (4.1–4.9) | 0.1 | 4.6 (4.3–4.9) | 4.8 (4.5–5.6) | 0.16 | 0.18 | 0.004 |
TNF | 7.3 (2.7–7.90) | 8.2 (7.7–8.5) | <0.001 | 1.4 (1.1–2.0) | 3.2 (2.4–4.9) | <0.001 | <0.001 | 0.002 |
IRIS: immune reconstitution inflammatory syndrome; IL: interleukin; IFN: interferon; GM-CSF: granulocyte-macrophage colony-stimulating factor; TGF: tumour growth factor; TNF: tumour necrosis factor. The p-values are uncorrected for multiple comparisons in the table but multiple comparisons were factored in the analysis (see text). Lower values indicate high transcript abundance of the gene of interest.