Pre-capillary PH | No pre-capillary PH | p-value | |
Subjects n | 187 | 64 | |
Clinical parameter | |||
Age yrs | 56.3±15.8 | 60.9±15.5 | 0.045 |
Male | 71 (38.0) | 26 (40.6) | 0.77 |
6MWD m | 336±139 | 367±117 | 0.15 |
NYHA classes III+IV | 123 (65.8) | 29 (45.3) | 0.005 |
Serum NT-proBNP pg·mL−1 | 1348±1693 | 478±1055 | <0.001 |
Serum creatinine mg·dL−1 | 1.1±0.3 | 1.1±0.3 | 0.77 |
Pa,CO2 mmHg | 34.5±5.3 | 37.5±4.3 | <0.001 |
Associated medical condition | 52 (27.8) | 5 (7.8) | <0.001 |
Transthoracic echocardiography parameter | |||
Ppa,sys mmHg | 82.2±27.2 | 50.0±13.4 | <0.001 |
Right atrial diameter mm | 58.0±9.5 | 54.6±8.0 | 0.012 |
Right atrial pressure mmHg | 10.0±4.0 | 6.8±2.4 | <0.001 |
TR severity: moderate + severe | 81 (43.3) | 17 (26.6) | 0.017 |
Right ventricular dysfunction | 108 (61.4) | 2 (3.2) | <0.001 |
Right ventricular diameter mm | 43.8±8.3 | 35.0±5.9 | <0.001 |
Left ventricular hypertrophy | 48 (28.9) | 31 (50.0) | 0.005 |
Left ventricular diastolic dysfunction | 79 (47.6) | 43 (69.4) | 0.004 |
Haemodynamic parameter | |||
Cardiac output L·min1# | 4.5±1.3 | 6.0±1.8 | <0.001 |
P̄pa mmHg | 49.3±14.0 | 23.5±7.5 | <0.001 |
PVR dyn·s·cm−5 | 751.4±365.3 | 158.2±86.2 | <0.001 |
Ppcw mmHg | 10.4±5.6 | 12.6±5.2 | 0.007 |
ECG parameter | |||
Heart rate beats·min−1 | 81.6±15.3 | 73.2±14.9 | <0.001 |
P-wave amplitude mV¶ | 0.21±0.08 | 0.15±0.05 | <0.001 |
P-wave axis° ¶ | 64.3±18.0 | 56.1±22.9 | 0.019 |
QRS axis° | 67.3±64.5 | 40.5±43.3 | <0.001 |
QRS duration ms | 102±20 | 97±19 | 0.14 |
Right ventricular hypertrophy+ | 92 (49.2) | 7 (10.9) | <0.001 |
Right bundle branch block | 66 (35.3) | 4 (6.3) | <0.001 |
Left bundle branch block | 2 (1.1) | 8 (12.5) | <0.001 |
Right ventricular strain | 147 (78.6) | 5 (7.8) | <0.001 |
Left ventricular strain | 16 (8.6) | 7 (10.9) | 0.62 |
QT interval ms | 384±38 | 390±45 | 0.32 |
Corrected QT interval | 434±34 | 424±31 | 0.041 |
Data are presented as mean±sd or n (%), unless otherwise stated. 6MWD: 6-min walk distance; NYHA: New York Heart Association; NT-proBNP: N-terminal brain natriuretic peptide; Pa,CO2: arterial carbon dioxide tension; Ppa,sys: systolic pulmonary artery pressure; TR: tricuspid valve regurgitation; P̄pa: mean pulmonary artery pressure; PVR: pulmonary vascular resistance; Ppcw; pulmonary capillary wedge pressure. #: derived from measurements based on the thermodilution method; ¶: 19 patients were excluded from p-wave analysis because of atrial fibrillation; +: diagnosed when the ratio of R and S in lead V1 was >1.