| Baseline values | ||||
| Sham | MI | Bos100 | Bos200 | |
| Troponin-T μg·L−1 | <0.01 | 8.18±0.43# | 7.23±0.56# | 6.65±0.40#,+ |
| LV wall motion abnormality % | 0 | 48±3# | 47±3# | 46±4# |
| LV wall motion score index | 1.01±0.01 | 1.90±0.09# | 1.88±0.05# | 1.76±0.08# |
| LV end-diastolic dimension mm | 7.4±0.1 | 9.9±0.2# | 10.1±0.2# | 9.9±0.2# |
| LV end-systolic dimension mm | 3.6±0.2 | 8.3±0.2# | 8.6±0.3# | 8.3±0.2# |
| FS % | 51.2±1.8 | 16.4±1.4# | 15.6±1.8# | 16.6±1.3# |
| LV end-diastolic area mm2 | 44.7±2.3 | 78.1±2.0# | 79.2±2.9# | 73.1±2.9# |
| LV end-systolic area mm2 | 15.6±1.4 | 53.2±2.4# | 55.1±2.7# | 50.4±3.6# |
| FAC % | 65.8±2.0 | 32.0±2.4# | 30.6±2.1# | 31.8±2.7# |
| RVDd mm | 3.3±0.1 | 3.2±0.1 | 3.2±0.1 | 3.1±0.1 |
| RVET ms | 83.4±1.9 | 85.3±2.2 | 86.1±1.8 | 80.9±1.8 |
| TVc-o | 91.7±2.8 | 115.3±4.3** | 113.6±3.7** | 114.1±5.1** |
| RVMPI | 0.10±0.04 | 0.36±0.05** | 0.33±0.06** | 0.41±0.05# |
| TAPSE mm | 3.1±0.2 | 2.6±0.1¶ | 2.8±0.2 | 2.5±0.2¶ |
Data are presented as mean±sem. MI: myocardial infarction; Bos100: bosentan 100 mg·kg−1·day−1; Bos200: bosentan 200 mg·kg−1·day−1; LV: left ventricular; FS: fractional shortening; FAC: Fractional area changes; RVDd: right ventricular end-diastolic dimension; RVET: right ventricular ejection time; TVc-o: tricuspid valve closing to opening; RVMPI: right ventricular myocardial performance index; TAPSE: tricuspid annulus plane systolic excursion. #: p<0.0001 versus sham; ¶: p<0.05 versus sham; +: p<0.05 versus MI. **: p<0.01 versus sham.