| Experimental group | MMP-9 ng·mL−1 | MIP-2 pg·mL−1 | MCP-1 pg·mL−1 | TNF-α pg·mL−1 | IL-6 pg·mL−1 |
| AOO/Veh/AOO | 0.14±0.26 | 9.66±1.91 | 17.17±7.75 | 371.0±170.9 | 220.4±67.1 |
| AOO/Veh/TDI | 1.59±1.21 | 12.90±1.64 | 25.67±11.39 | 811.9±415.0 | 260.1±116.0 |
| TDI/Veh/TDI | 2.55±2.30* | 15.45±6.74 | 24.38±8.55 | 524.3±226.1 | 136.9±74.8 |
| AOO/TiO2/AOO | 0.62±0.43 | 9.52±0.67 | 15.71±8.28 | 360.5±129.4 | 206.2±63.7 |
| AOO/TiO2/TDI | 1.81±2.06 | 10.62±2.14 | 26.37±13.37 | 1111.0±649.0** | 265.3±119.4 |
| TDI/TiO2/TDI | 3.97±2.31** | 18.65±9.87* | 26.13±9.21 | 323.0±180.6 | 135.1±115.6 |
| AOO/Au/AOO | 1.34±1.59 | 10.10±1.29 | 14.90±4.87 | 304.2±114.8 | 307.5±90.8 |
| AOO/Au/TDI | 2.68±2.78 | 13.62±3.85 | 31.91±11.93 | 957.2±490.5* | 300.6±114.4 |
| TDI/Au/TDI | 4.56±1.57** | 20.25±7.89** | 29.89±17.96 | 189.8±127.1# | 71.4±81.1* |
Data are presented as mean±sd. Concentrations of matrix metallopeptidase (MMP)-9, macrophage inflammatory protein (MIP)-2, monocyte chemotactic protein (MCP)-1, tumour necrosis factor (TNF)-α and interleukin (IL)-6 were measured in BAL via standard ELISA. Experimental groups are identical to figure 2. n = 5–9 per group. A: acetone; OO: olive oil; Veh: vehicle; TDI: toluene diisocyanate; TiO2: titanium dioxide; Au: gold. *: p<0.05 compared with AOO/Veh/AOO; **: p<0.01 compared with AOO/Veh/AOO; #: p<0.05 compared with TDI/Veh/TDI.