Table 6– Randomised controlled latent tuberculosis (TB) infection treatment trials comparing efficacy of isoniazid versus other regimens
Lead author [ref.]Site (year)TSTCases/number treated#RR (95% CI)
HHRRZ(H)RHRRZ(H)R
Whalen 99Uganda (1997)Positive7/536§9/55610/462ƒ0.81 (0.30–2.15)0.60 (0.23–1.57)
Mwinga 102Zambia (1998)Positive4/52##2/49¶¶1.88 (0.36–9.83)
Negative14/178##13/173¶¶1.05 (0.51–2.16)
Unknown9/122##10/129¶¶0.95 (0.40–2.26)
Halsey 111Haiti (1998)Positive14/370##19/380§§0.76 (0.39–1.49)
Martinez 112Spain (2000)Positive3/21++1/263.71 (0.42–33.15)
Negative1/43++1/431.00 (0.06–15.48)
Gordin 113International (2000)Positive29/792++28/791ƒƒ1.03 (0.62–1.72)
Rivero 104Spain (2003)Anergic3/83§3/821/77ƒƒ0.99 (0.21–4.75)0.70 (0.16–3.05)
Rivero 114Spain (2007)Positive4/108§5/1032/105ƒƒ0.76 (0.21–2.76)1.94 (0.36–10.39)
Girling 73+Hong Kong (1992)Positive###20/100§19/8717/1030.92 (0.52–1.60)1.21 (0.68–2.18)
  • TST: tuberculin skin test; RR: risk ratio; H: isoniazid for 6–12 months; HR: isoniazid and rifampicin daily for 3 months; RZ(H): rifampicin plus pyrazinamide or rifampicin plus pyrazinamide plus isoniazid for 2–3 months; R: rifampicin daily for 3 months. #: active TB cases within 1–5 yrs of follow-up (variable and with considerable attrition); : isoniazid versus regimen; +: non-HIV; §: isoniazid daily for 6 months; ƒ: isoniazid plus rifampicin plus pyrazinamide daily for 3 months; ##: isoniazid twice weekly for 6 months; ¶¶: rifampicin plus pyrazinamide twice weekly for 3 months; ++: isoniazid daily for 12 months; §§: rifampicin plus pyrazinamide twice weekly for 2 months; ƒƒ: rifampicin plus pyrazinamide daily for 2 months; ###: mainly TST-positive.