Table 1– Description of the German and Dutch AirAllerg study population at age 6 yrs
LISA and GINIPIAMAp-value
Subjects n358332
Cohort type
 LISA138 (39)
 GINI220 (61)
Males204/358 (57)186/332 (56)0.859
Parental allergy#294/358 (82)260/332 (78)0.246
Parental education
 High198/358 (55)193/332 (56)0.502
 Medium106/358 (30)110/332 (33)0.360
 Low54/358 (15)29/332 (9)0.014
Visible mould in any room at 6 yrs of age56/323 (17)108/329 (33)<0.001
Dwelling considered damp at 6 yrs of age10/339 (3)NANA
Any pets in child’s home at 6 yrs of age86/345 (25)133/326 (41)<0.001
Day-care attendance
 1st year5/318 (1)83/330 (25)<0.001
 2nd year29/306 (8)85/323 (26)<0.001
 3rd year68/319 (19)133/326 (41)<0.001
 4th year257/324 (72)244/324 (75)0.260
Breastfeeding+179/333 (54)201/328 (61)0.060
Smoking in child’s home at 6 yrs of age72/344 (21)89/331 (27)0.084
Maternal smoking during pregnancy50/357 (14)45/328 (14)0.985
Moving home§ at 6 yrs of age39/346 (11)13/330 (4)<0.001
Physician-diagnosed asthmaƒ17/343 (5)27/328 (8)0.119
Physician-diagnosed allergic rhinitisƒ,##47/342 (14)24/327 (7)0.010
Allergic respiratory symptomsƒ
 Rhinoconjunctivitis48/343 (14)28/327 (7)0.036
 Wheezing43/341 (13)48/331 (15)0.546
 Dry cough¶¶56/343 (16)80/330 (24)0.014
Physician-diagnosed infections of the upper airwaysƒ275/342 (80)47/329 (14)<0.001
Dust sampling season++
 Autumn48/358 (13)101/332 (30)<0.001
 Winter57/358 (16)113/332 (34)<0.001
 Spring253/358 (71)118/332 (36)<0.001
  • Data are presented as n, n (%) or n/N (%), unless otherwise stated. Bold indicates statistically significant p-values. LISA: Lifestyle Related Factors on the Immune System and the Development of Allergies in Childhood; GINI: German Infant Nutritional Intervention; PIAMA: Prevention and Incidence of Asthma and Mite Allergy; NA: not available. #: defined as asthma and/or hay fever and/or eczema (at least one parent) for LISA and GINI and as asthma and/or allergy to house dust (mite) or pets, and/or hay fever in at least one parent for PIAMA; : categorised according to the German educational system as less than, equal to and more than grade 10 for low, medium and high, respectively, for LISA and GINI and as the highest attained educational level of mother and father, where low is primary school, lower vocational or lower secondary education, medium is intermediate vocational education or intermediate/ higher secondary education, and high is higher vocational education and university for PIAMA; +: defined as exclusive breastfeeding during the first 4 months of life for LISA and GINI and as any breastfeeding at the age of 3 months for PIAMA; §: defined as moving home in the previous 24 months for GINI, and as moving home in the previous 12 months for LISA and PIAMA; ƒ: in the previous 12 months; ##: defined as hayfever and/or allergic rhinitis (all seasons) for LISA and GINI, and as hayfever ever for PIAMA; ¶¶: defined as nocturnal dry cough for PIAMA; ++: autumn defined as October–November, winter as December–February and spring as March–April.