Case | Smoking | Clinical presentation | Crackles | DL,CO % pred | Pa,O2 mmHg | HRCT scan¶ | BAL | ||
Lymphocytes % | Neutrophils % | Total ×104 cells·mL−1 | |||||||
1 | No | Chronic progressive | Yes | 47 | 66 | Ground glass, nodules, honeycombing and reticular patterns | 61 | 10 | 41 |
2 | Nonsmoker | Acute intermittent | No | 86 | ND | Normal | 21 | 12 | 52 |
3 | 5 cigarettes·day−1 | Acute intermittent | No | 65 | 78 | Ground glass | 56 | 10 | 62 |
4 | Ex-smoker 10 pack-yrs | Acute intermittent | Yes | 72 | 82 | Normal | 25 | 4 | 57 |
5 | Nonsmoker | Acute intermittent | No | 80 | 95 | Normal | 32 | 12 | 42 |
6 | Nonsmoker | Acute intermittent | Yes | 70 | 92 | Ground glass | 45 | 5 | 54 |
7 | Nonsmoker | Acute intermittent | Yes | 79 | ND | Ground glass | ND | ND | ND |
8 | Ex-smoker 30 pack-yrs | Acute progressive | Yes | 67 | 78 | Ground glass | 42 | 6 | 78 |
9 | Ex-smoker 12 pack-yrs | Acute intermittent | Yes | 76 | ND | Ground glass, consolidations | ND | ND | ND |
10 | Nonsmoker | Acute progressive | Yes | 38 | 63 | Ground glass | 70 | 5 | 66 |
11 | Nonsmoker | Acute intermittent | Yes | 68 | 92 | Ground glass | 30 | 6 | 51 |
12 | Nonsmoker | Chronic progressive | Yes | 50 | 86 | Ground glass | 56 | 5 | 55 |
13 | 55 pack-yrs | Chronic progressive | Yes | 54 | 72 | Ground glass | 23 | 3 | 67 |
DL,CO: diffusing capacity of the lung for carbon monoxide; % pred: % predicted; Pa,O2: arterial oxygen tension; HRCT: high-resolution computed tomography; BAL: bronchoalveolar lavage; ND: not determinated. #: n = 13; ¶: HRCT scan was perfomed 6–8 weeks after exposure in cases 2–5.