| Degree of exposure to the index case and location of possible transmission |
| Risk of prior infection with Mycobacterium tuberculosis (e.g. foreign-born or prior tuberculosis contact) |
| BCG vaccination status |
| Previous TST and/or IGRA result |
| Age |
| Tuberculosis history (tuberculosis, latent infection with M. tuberculosis, previous antituberculosis chemotherapy or preventive therapy) |
| Medical history and comorbidity (immune status (table 2), risk of hepatitis or co-medication) |
| Symptoms of tuberculosis |
| Conditions associated with reduced adherence |
BCG: Bacille Calmette–Guérin; TST: tuberculin skin test; IGRA: interferon-γ release assay.