Table 3– Genotype frequencies for the rs1489759 Hedgehog-interacting protein single-nucleotide polymorphism in chronic obstructive pulmonary disease (COPD) and lung cancer (LC) (total and subgrouped by pre-operative lung function) cohorts compared with smoking controls

	Subjects	A	G	OR (95% CI)^#	p-value^#	AA	AG	GG	OR (95% CI)^¶	p-value^¶
Primary cohorts
Controls	484 (99)	579 (60)	389 (40)			178 (37)	223 (46)	83 (17)
COPD	457 (99)	594 (65)	320 (35)	0.80 (0.66–0.97)	0.002	187 (41)	220 (48)	50 (11)	0.59 (0.40–0.88)	0.006
LC	445 (99)	563 (63)	327 (37)	0.86 (0.71–1.05)	0.127	174 (39)	215 (48)	56 (13)	0.70 (0.47–1.02)	0.051
LC subgroup analyses
LC with COPD	213	292 (69)	134 (31)	0.68 (0.53–0.88)	0.002	103 (48)	86 (40)	24 (11)	0.61 (0.39–1.02)	0.047
LC only	206	276 (67)	136 (33)	0.73 (0.57–0.94)	0.01	92 (47)	82 (40)	27 (13)	0.73 (0.44–1.19)	0.185
COPD subgroup analysis
COPD and LC with COPD	670	869 (65)	471 (35)	0.81 (0.68–0.96)	0.014	273 (41)	323 (48)	74 (11)	0.60 (0.42–0.85)	0.003

Data are presented as n or n (call rate %), unless otherwise stated. ^#: G versus A compared with matched smoking controls (Mantel–Haenszel); ^¶: GG versus AG/AA compared with matched smoking controls (Mantel–Haenszel).