Table 1– Chromosomal loci associated with chronic obstructive pulmonary disease (COPD) and forced expiratory volume in 1 s (FEV₁) and lung cancer from genome-wide association studies

Disease	Chromosomal loci	Candidate genes	[Ref.]^#
COPD^¶ and FEV₁	15q25	CHRNA3/5	23
	4q31	HHIP, GYPA	23–26
	6p21	BAT3/AGER	25, 26
	5q33	HTR4	25, 26
	15q11	SNRPN	27
	1q21	CRP/IL6R	27
	4q24	GSTCD	25, 26
Lung cancer	15q25	CHRNA3/5	20–22
	4q31	GYPA⁺	20
	5p15	TERT/CRR9	2, 20, 21
	1q21-23	CRP/IL6R	20
	6p21	BAT3	2, 20, 21
	3q28	IL1RAP	20

^#: available at www.genome.gov/gwastudies (last accessed February 25, 2010); ^¶: defined on the basis of forced expiratory volume in 1 s measurements; ⁺: did not reach genome-wide significance levels.