Table 5– Assessment of morning responsiveness to change according to Capacity of Daily Living during the Morning (CDLM) questionnaire and Global Chest Symptoms Questionnaire (GCSQ) scores from run-in to the end of treatment

	Subjects n	Mean			ES	SRM	t-statistic
	Subjects n	Run-in	End	Change	ES	SRM	t-statistic
CDLM
Study 1	230	4.13	4.33	0.16	0.24	0.44	6.73***
Study 2	316	3.61	3.86	0.22	0.23	0.36	6.36***
GCSQ
Study 1	287	1.41	1.26	-0.15	0.24	0.34	5.77***
Study 2	418	1.61	1.41	-0.20	0.32	0.42	8.74***

ES: effect size; SRM: standardised response mean. ***: p<0.001. Analyses of responsiveness were made for patients who received a change in treatment compared to the run-in period, i.e. not including the placebo group in Study 1, but including both active treatment groups in Study 2.