Table 2– Genes for which genetic variants were reported to be associated with asthma and for which epigenetic data has been published

Gene	Description	Tissue/material analysed	[Ref.]
**ADAM33^#,¶**	Tissue-specific methylation, but no correlation with asthma	Bronchoscopy, human primary bronchial cell culture/cell lines H292 and A549	93
*GSTP1^#*	Differently methylated in cancer patients	Breast cancer incision biopsy	72
*IKZF3*⁺	DNA methylation and histone modifications influence expression cell specific	Human melanocytes/cell lines Daudi, Jurkat, U937 and 1106 melanoma	94
*IL10*^¶	Hypermethylation in persons who were periconceptionally exposed to famine	Human whole blood	87
**IL13^#,¶**	Reduced promoter methylation in Th2 cells compared with Th1 cells	Human neonatal CD4+ T-cells	95
**IL4^#,¶**	IL4 concentration in asthmatics is correlated with demethylation of IL4	Human blood PBMCs	96
**IL4R^#,¶**	DNA methylation related to hepatitis B virus infection	Human hepatocellular carcinoma and adjacent non-tumour tissues/cell lines Huh7 and HepG2	97
*MS4A2*^¶	Failure to find an association of DNA methylation and atopy	Human white blood cells	98
*MYB*⁺	Hypermethylation only in stimulated Bloom syndrome cells	B-LCLs from both a Bloom syndrome patient and a normal subject	99
*PDE4D*⁺	Phenotypically dependent level of histone acetylation controlling expression	Rats aortic tissue/cell lines VSMC and NIH 3T3	100
**TNF^#,¶**	DNA demethylation and TNF-α production in THP-1 cells after PMA or LPS stimulation	Cell lines K562, THP-1 and HL60	101
17q21 locus⁺	Allele-specific chromatin remodelling associated with asthma	Human lymphoblastoid cells	102

Th: T-helper type cells; IL: interleukin; TNF: tumour necrosis factor; PMA: phorbol myristate acetate; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cell; B-LCL: B-lymphocyte cell line. ^#: association with asthma in at least five independent studies; ^¶: gene reported as one of the most often published asthma candidate genes in a recent comprehensive review 88; ⁺: association with asthma reported in a genome-wide study.