Table 3—

Multivariate predictors of death on Cox's proportional hazards analysis in all pulmonary arterial hypertension (PAH) patients

Hazard ratio
Regression 1#Regression 2Regression 3+
Age at diagnosis per decade increase1.22 (1.11–1.35)1.19 (1.08–1.31)1.18 (1.07–1.30)
Connective tissue disease aetiology1.70 (1.29–2.24)1.66 (1.25–2.20)1.64 (1.23–2.18)
Functional class per 1-class increase1.43 (1.20–1.72)1.60 (1.34–1.92)1.42 (1.17–1.71)
Right atrial pressure per 5-mmHg increase1.30 (1.18–1.44)
Mean pulmonary arterial pressure per 5-mmHg increase1.02 (0.97–1.08)
Cardiac index per 1-L·min−1·m−2 increase0.79 (0.65–0.96)
  • Data are presented with 95% confidence intervals in parentheses. Likelihood ratio (LR) analysis was performed versus the model with age, connective tissue disease aetiology and functional class alone. The model with age, connective tissue disease aetiology, functional class and right atrial pressure is the best model. Adding cardiac index does not help discriminate further (LR test for model 1 with cardiac index versus model 1 without cardiac index: p = 0.47). #: independent variables: age at diagnosis, connective tissue disease aetiology of PAH, functional class and right atrial pressure (p<0.0001 on LR analysis); : independent variables: age at diagnosis, connective tissue disease aetiology of PAH, functional class and mean pulmonary arterial pressure (p = 0.35 on LR analysis); +: independent variables: age at diagnosis, connective tissue disease aetiology of PAH, functional class and cardiac index (p = 0.013 on LR analysis).