Table 1—

Characteristics and antimycobacterial immune responses in HIV positive patients, HIV positive/Mycobacterium tuberculosis co-infected patients and healthy individuals from Kampala, Uganda

Variables	HIV+ patients			p-value^#	HIV+ patients	HIV+/TB patients	p-value^¶	Healthy controls	p-value⁺
Variables	CD4 cell counts <100 cells·μL⁻¹	CD4 cell counts 100–250 cells·μL⁻¹	CD4 cell counts >250 cells·μL⁻¹	p-value^#	HIV+ patients	HIV+/TB patients	p-value^¶	Healthy controls	p-value⁺
Subjects n	10	33	66		109	19		7
Males	4 (40)	4 (12.1)	17 (25.8)	0.12^§	25 (22.9)	11 (57.9)	0.004^§	2 (28.6)	0.008^§
Age yrs	34.3±6.6	35.6±9.8	33.4±7.7	0.48^ƒ	34.1±8.3	33.4±6	0.7^##	25.7±4.9	0.03^ƒ
CD4 cell count cells·μL⁻¹	64 (43)	179 (68)	368.5 (206)	0.0001⁺⁺	283 (226)	182 (118)	0.0008^¶¶
HIV viral load copies·mL⁻¹	104004 (150718)	55234 (124166)	22058 (42692)	0.01⁺⁺	26805 (95003)	71330.5 (245202)	0.01^¶¶
HIV viral load log copies·mL⁻¹	5±0.6	4.5±0.8	4.3±0.7	0.01^ƒ	4.4±0.8	4.9±0.7	0.01^##
TST	8 (80)	27 (81.8)	54 (81.8)		89 (81.7)			7 (100)	0.21^§
TST induration	0 (2.5)	5 (15)	8 (13)	0.01⁺⁺	5 (18)			18 (7)	0.01^¶¶
TST induration >5 mm	1/8 (12.5)	9/27 (33.3)	32/54 (59.3)	0.01^§	42/89 (47.2)			7 (100)	0.01^§
QFT-G-IT positive result	1 (10)	22 (66.7)	51 (77.3)	<0.0001^§	74 (67.9)	13 (68.4)	0.97^§	7 (100)	0.5^§
QFT-G-IT indeter. result	1 (10)		3 (4.6)	0.48^§	3 (3.7)
Mitogen	1.4( 2.1)	2.9 (6.1)	3.2 (6)	0.03⁺⁺	2.9 (5.9)	0.4; 1	<0.00001^¶¶	5.8; 2.8	0.0001⁺⁺
ESAT-6/CFP-10/TB7.7	0.25 (0.3)	0.5 (1)	0.9 (1.6)	0.0009⁺⁺	0.7 (1.4)	0.9 (1.2)	0.67^¶¶	1.3 (1.7)	0.22⁺⁺
T-SPOT TB positive result	7 (70)	19 (57.6)	33 (50)	0.63^§	59 (54)	17 (89.5)	0.004^§	5 (71.4)	0.001^§
T-SPOT TB indeter. result		2 (6.1)	2 (3)	0.46^§	4 (3.7)	2 (10.5)	0.2^§
ESAT-6	3.5 (6)	6 (21)	7.5 (22)	0.35⁺⁺	6 (18)	14 (34)	0.03^¶¶	12 (13)	0.09⁺⁺
CFP-10	7 (7)	6 (23)	8.5 (19)	0.95⁺⁺	7 (18)	84 (102)	<0.00001^¶¶	10 (19)	0.0001⁺⁺

Data are presented as mean±sd, unless otherwise stated. Data for males, tuberculin skin test (TST) and all QuantiFERON-TB-Gold In-Tube (QFT-G-IT) and T-SPOT TB data are presented as n (%). Data for CD4 cell count, HIV viral load copies, TST induration, mitogen, early secretaory antigenic target-6 (ESTAT-6) and culture filtrate protein-10 (CFP-10) are presented as median (interquartile range). TST induration >5 mm is presented as n/N (%). indeter.: indeterminate. ^#: comparison of the demographic and clinical characteristics among HIV+ patients with CD4 cell counts <100 cells·μL⁻¹, those with 100–250 cells·μL⁻¹ and those with >250/μl; ^¶: comparison of the demographic and clinical characteristics among HIV+ patients and HIV+/TB co-infected patients; ⁺: comparison of the demographic and clinical characteristics among HIV+ patients, HIV+/TB co-infected patients and healthy controls; ^§: Fisher's exact test; ^ƒ: ANOVA; ^##: two independent samples, unpaired t-test; ^¶¶: Wilcoxon Mann–Whitney test; ⁺⁺: Kruskal–Wallis test.