Antibody | Current value | Mesothelioma | Positivity | Adenocarcinoma | Positivity |
Mesothelioma | |||||
Calretinin | Essential | Positive(nuclear and cytoplasmic) | 80–100% | Usually negative | 5–10% cytoplasmic positivity of lung adenocarcinoma |
Keratin CK5/6 | Useful | Positive(cytoplasmic) | 60–100% | Usually negative | 2–10% focal positivity |
WT-1 | Useful | Positive(nuclear) | 43–93% | Lung adenocarcinoma are negative | 0% |
EMA | Useful | Positive(membranous) | 60–100% | Positive (cytoplasmic) | 70–100% |
Podoplanin | Useful | Positive(membranous) | 80–100% | Usually negative | 7% focal positivity |
Lung adenocarcinoma | |||||
CEA monoclonal | Very useful | Almost invariably negative | 0% | Positive (cytoplasmic) | 50–90% |
CD15 | Useful | Never expressed in mesothelioma | 0% | Positive (membranous) | 50–70% focally positive |
Ber-EP4 | Very useful | Positive or negative (membranous) | Up to 20% can be focally positive | Positive (membranous) | 95–100% |
TTF-1 | Very useful | Never expressed | 0% | Positive (nuclear) | 70–85% of lung adenocarcinoma |
B72.3 | Very useful | Rarely positive | <1% | Positive (cytoplasmic) | 70–85% of lung adenocarcinoma |
Breast carcinoma | |||||
ER | Very useful | Never expressed in mesothelioma | 0% | Positive nuclear staining | ∼70% |
CK5/6: cytokeratin 5/6; WT-1: Wilms tumour antigen-1; EMA: epithelial membrane antigen; CEA: carcinoembryonic antigen; TTF-1: thyroid transcription factor-1; ER: endoplasmic reticulum marker.