Change in PC20 methacholine and PC20 adenosine (doubling doses) compared with placebo#
| CIC 320 µg·day−1 | CIC 640 µg·day−1 | FP 500 µg·day−1 | FP 1000 µg·day−1 | |
| Subjects n | 29 | 29 | 30 | 30 |
| Methacholine | ||||
| LS mean±sem | 0.3±0.3 | 0.5±0.3 | 0.6±0.3 | 0.7±0.3 |
| 95% CI | -0.3–0.8 | 0.0–1.1 | 0.1–1.2 | 0.1–1.3 |
| p-value | 0.3356 | 0.0645 | 0.0228 | 0.0145 |
| Adenosine | ||||
| LS mean±sem | 0.9±0.4 | 1.6±0.4 | 1.8±0.4 | 1.4±0.4 |
| 95% CI | 0.1–1.7 | 0.6–2.4 | 1.0–2.6 | 0.6–2.2 |
| p-value | 0.0218 | ≤0.0001 | ≤0.0001 | 0.0007 |
PC20: provocative concentration leading to a 20% decrease in forced expiratory volume in 1 s; CIC: ciclesonide; FP: fluticasone propionate; LS: least squares; CI: confidence interval. #: maintenance dose of CIC 160 µg·day−1.