Association of tumour necrosis factor-α (TNFA) -308 G/A+A/A genotype and asthma stratified by body mass index (BMI) categories
| All | Atopic asthma | Nonatopic asthma | ||||
| OR (95% CI)# | p-value¶ | OR (95% CI)# | p-value¶ | OR (95% CI)# | p-value¶ | |
| Current asthma | 1.34 (1.10–1.62) | 1.35 (1.05–1.72) | 1.33 (0.93–1.87) | |||
| BMI <20 | 1.94 (1.00–3.68) | 0.24 | 2.32 (1.02–5.24) | 0.23 | 2.29 (0.68–7.43) | 0.21 |
| BMI 20 to <25 | 1.27 (0.97–1.64) | ref | 1.25 (0.90–1.73) | ref | 1.05 (0.63–1.70) | ref |
| BMI 25 to <30 | 1.52 (0.99–2.30) | 0.53 | 1.64 (0.95–2.78) | 0.43 | 1.17 (0.54–2.38) | 0.83 |
| BMI ≥30 | 1.70 (0.89–3.19) | 0.41 | 1.05 (0.41–2.55) | 0.66 | 3.15 (1.18–8.54) | 0.05 |
| Physician-diagnosed asthma | 1.10 (0.93–1.29) | 1.18 (0.96–1.46) | 0.94 (0.70–1.24) | |||
| BMI <20 | 1.43 (0.85–2.36) | 0.30 | 1.61 (0.84–3.06) | 0.45 | 1.58 (0.66–3.56) | 0.10 |
| BMI 20 to <25 | 1.04 (0.83–1.09) | ref | 1.09 (0.83–1.43) | ref | 0.70 (0.45–1.06) | ref |
| BMI 25 to <30 | 1.13 (0.78–1.62) | 0.80 | 1.32 (0.80–2.12) | 0.58 | 0.93 (0.52–1.59) | 0.46 |
| BMI ≥30 | 1.76 (0.99–3.10) | 0.10 | 1.32 (0.57–2.99) | 0.78 | 1.93 (0.85–4.26) | 0.03 |
OR: odds ratio; CI: confidence interval; ref: reference value. #: logistic regression adjusted by country, sex, age and smoking status. ¶: for interaction between TNF -308 G/A+A/A and BMI categories; reference categories BMI 20 to <25 kg·m−2 and G/G genotype.