Results of studies that assess the effectiveness and safety of endobronchial ultrasound(EBUS)-guided transbronchial needle aspiration (TBNA) in sarcoidosis and lymphoma
| Author and year | Type of study | Patients included | Reference/comparison test | Diagnostic performance | P | Adequate sample | Safety | |||
| S | Sp | PPV | NPV | |||||||
| Diagnosis of sarcoidosis | ||||||||||
| Wong 27 | Prospective | 65 patients with clinical and radiological findings suggestive of sarcoidosis and enlargement of lymph and/or mediastinal nodes (>1 cm) | Positive cytologies taken as final diagnosis In benign results, mediastinoscopy (n = 5), thoracoscopy (n = 1) and clinical follow-up (n = 3) | 91.8% | 87.5%# | 11%# | 100% | 95.3% | No important complications | |
| Oki 28 | Prospective | 15 patients with clinical and radiological findings suggestive of sarcoidosis and enlargement of lymph and/or mediastinal nodes (>1 cm) | TBNA in all patients | Diagnostic performance of EBUS–TBNA 93% | 93.3% | No complications | ||||
| Diagnostic performance of TBNA 94% | ||||||||||
| Garwood 29 | Prospective | 50 patients with suspicion of sarcoidosis (90% with clinical symptoms and adenopathy on radiographic imaging) | Positive cytologies taken as final diagnosis In benign results, histology samples (obtained by EBUS–TBNA or transbronchial lung biopsy, endobronchial biopsy or in one case supraclavicular lymph node aspiration) or follow-up | 88% | 100% | 100% | 12.5% | 98% | 88% | No complications |
| Diagnosis of lymphoma | ||||||||||
| Kennedy 30 | Retrospective | 25 patients with suspected lymphoma (clinical, radiological data or other previous lymphoma) | Results of the biopsy and clinical and radiological follow-up of patients for 6 months | 90.9% | 100% | 100% | 92.6% | 44% | 96% | No complications |
S: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; P: prevalence. #: For this calculation, four cases without definitive diagnosis were deemed positive.