Studies of ventilatory control in subjects with sleep-disordered breathing (SDB), families and controls
| Reference | Subjects n | HVR | HCVR | HCVR and loading | ||
| SDB | F | Controls | ||||
| 54 | 10 | 12 | 9 | SDB and family lower than controls | No difference across groups | Respiratory impedance greater in family, c.f. controls |
| 55 | 8 | 8 | Decreased V′E in SDB | |||
| 56 | 13# | 32 | No difference between relatives | No difference between relatives | ||
| 56 | 16 | 26 | No difference between relatives | No difference between relatives | ||
| 57 | 35 | 17 | No difference between groups | Lower response in SDB | ||
| 58 | 16 | 12 | Greater increase V′E in SDB | No difference between groups | ||
| 59 | 20¶ | 19 | No difference between groups | No difference between groups | ||
| 60 | 37 | 14 | No difference between groups | No difference between groups | ||
| 61 | 151 | Total subjects 485: ventilatory variability index calculated. Multiple linear regression showed association with AHI of increased ventilatory variability. | ||||
Patients with SDB are normocapnic unless otherwise indicated. F: family members; HVR: hypoxic ventilatory response; HCVR: hypercapnic ventilatory response; V′E: minute ventilation; AHI: apnoea/hypopnoea index. #: hypercapnic patients; ¶: children with mean±sd age 8±3 yrs.