Table 2—

Influence of mitochondrial inhibition on hypoxic pulmonary vasoconstriction(HPV) and normoxic vessel tone

	ROS	Normoxic tone	HPV	Model	[Ref.]
Rotenone	↓	↑	Inhibited	Whole lung and PASMCs	89
	↓	↑	Inhibited	PA and PASMCs, opposite in renal tissue	92
		↑	Inhibited, unspecifically	Isolated lung	108
	↓	↑		Vessel wall	93
		↑	Inhibited	Buffer perfused rat lungs, PASMCs	84
		No change with inhibited NO	Inhibited, specificity pronounced under blocked NO	Isolated rabbit lung	109
		No change	Inhibited	PAs	119
3-NPA	Prevents hypoxia induced increase	↑	Inhibited	Intraacinar arteries	121
		No change	Inhibited	Isolated lung	109
Succinate		No change	Reverses effect of rotenone	PAs	119
	SDH activity decreased during hypoxia	No change	Inhibited (unspecifically), fumarate delays beginning, malate prevents unspecifically	Intraacinar arteries	121
Antimycin A	↓ in normoxia and hypoxia	↑	Inhibited	Whole lung	89
	↓	↑	Inhibited	PA and PASMCs opposite in renal tissue	92
		↑	Inhibited, unspecifically	Isolated rat lung	108
		↑	Inhibited unspecifically in high concentrations, no change in low concentrations	Buffer perfused lung	84
	↓ in normoxia and hypoxia	↑	Pronounced vasodilation	PA	121
		No change with inhibited NO	Inhibited unspecifically under blocked NO	Isolated lung	109
HQNO		↑	Inhibited specifically	Isolated lung	109
Myxothiazol	↓ during hypoxia		Decreased intracellular Ca²⁺ during hypoxia	PASMC	87
	↓ during hypoxia	No change	Inhibited	Buffer perfused rat lungs, PASMCs	84
		No change	Inhibited	IPA	119
		No change with inhibited NO	HPV inhibited unspecifically, especially under preblocked NO	Isolated lung	109
Cyanide	↑	↑, inhibited by SOD	No change	Whole lung PASMCs	89
	No change during hypoxia		Increased intracellular Ca²⁺ during hypoxia	PASMCs	87
		↑, inhibited by ebselen and myxo-thiazol	↑	Buffer perfused lung	84
		No change	No effect on phase 1, potentiates phase 2	PAs	119
		↑	Inhibited, unspecifically	Isolated rat lung	108
		↑	Inhibited, especially phase 2	Rabbit lung	92
Azide		↑	Inhibited, unspecifically	Isolated rat lung	108
	No change		Inhibited, unspecifically	PA	121

Vasoconstriction during normoxia when applying the inhibitor is usually smaller than HPV and of transient character. ROS: reactive oxygen specificity; 3-NPA: 3-nitropropionic acid; HQNO: 2n-heptyl-4-hydroxyquinoline-N-oxide; SDH: succinate dehydrogenase; No: nitric oxide; SOD: superoxide dismutase; PASMC: pulmonary arterial smooth muscle cells; PA: pulmonary arteries; IPA: intrapulmonary arteries. ↓: decrease; ↑: increase.