Baseline | 1 month | 3 months | 6 months | |
FEV1 L | 0.84±0.23 | 0.82±0.22 | 0.80±0.22 | 0.79±0.23 |
Difference L | -0.03±0.14 | -0.03±0.17 | -0.04±0.16* | |
Subjects n | 57 | 55 | 54 | 45 |
FVC L | 2.76±0.84 | 2.75±0.83 | 2.61±0.74 | 2.59±0.73 |
Difference L | -0.03±0.48 | -0.12±0.46 | -0.11±0.60* | |
Subjects n | 57 | 55 | 54 | 45 |
TLC L | 7.78±1.40 | 7.65±1.41 | 7.74±1.49 | 7.64±1.51 |
Difference L | -0.11±0.68 | -0.03±0.73 | -0.12±0.63 | |
Subjects n | 56 | 55 | 54 | 45 |
RV L | 4.90±1.04 | 4.90±1.05 | 5.10±1.15 | 4.98±1.26 |
Difference L | 0.03±0.87 | 0.19±0.93 | 0.02±0.94 | |
Subjects n | 56 | 55 | 54 | 45 |
DL,CO mL·min−1 | 9.50±3.13 | 9.67±3.26 | 8.97±3.06 | 9.10±2.76 |
Difference mL·min−1 | 0.09±2.11 | -0.49±2.17 | -0.29±1.99 | |
Subjects n | 56 | 54 | 54 | 45 |
6MWT m | 336±85 | 345±90 | 349±85 | 348±97 |
Difference m | 4±56 | 9±57 | 12±65 | |
Subjects n | 57 | 54 | 54 | 45 |
SGRQ | 58.2±12.6 | 52.7±13.6 | 54.5±18.0 | 50.0±19.1 |
Difference | -5.49±13.60** | -4.28±15.81* | -8.95±16.22# | |
n | 56 | 55 | 54 | 45 |
Data are presented as mean±sd, unless otherwise stated. FEV1: forced expiratory volume in one second; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; DL,CO: diffusing capacity of the lung for carbon monoxide; 6MWT: 6-min walk test; SGRQ: St George’s Respiratory Questionnaire. #: p<0.0001; *: p<0.05; **: p<0.01.