Cardiopulmonary haemodynamics at baseline and after therapy
| Placebo | Bosentan | p-value | |||
| Baseline | 12 weeks | Baseline | 12 weeks | ||
| Subjects n | 10 | 9 | 20 | 14 | |
| Cardiopulmonary haemodynamics | |||||
| Systolic Ppa mmHg# | 37 (20–42) | 33 (29–39) | 32 (29–38) | 30 (26–34) | 0.288 |
| RV fractional area change % | 34.2±11.8 | 43.9±7.9 | 42.7±11.0 | 50.5±6.8 | 0.935 |
| Tricuspid annular motion mm | 24.4±2.7 | 22.5±2.4 | 21.0±4.5 | 22.7±3.6 | 0.059 |
| Early diastolic velocity RV cm·s−1 | 0.44±0.09 | 0.40±0.08 | 0.44±0.11 | 0.41±0.12 | 0.512 |
| Late diastolic velocity RV | 0.46±0.12 | 0.46±0.09 | 0.44±0.13 | 0.39±0.07 | 0.338 |
| Early diastolic/late diastolic velocity RV | 1.00±0.30 | 0.88±0.15 | 0.99±0.23 | 1.07±0.33 | 0.142 |
| Tissue doppler imaging | |||||
| Early diastolic velocity cm·s−1 | 0.08±0.03 | 0.08±0.03 | 0.08±0.04 | 0.09±0.03 | 0.346 |
| Late diastolic velocity cm·s−1 | 0.14±0.05 | 0.15±0.02 | 0.14±0.05 | 0.15±0.05 | 0.890 |
| Systolic velocity cm·s−1 | 0.12±0.04 | 0.12±0.02 | 0.12±0.03 | 0.12±0.03 | 0.961 |
| Pulmonary vascular resistance (dyne×s)·cm5 | 145±28 | 182±23 | 158±30 | 154±45 | 0.006 |
| Cardiac index L·min·m2 | 3.3±0.79 | 3.39±0.58 | 2.45±0.41 | 2.66±0.65 | 0.296 |
Data are presented as median (interquartile range) or mean±sd, unless otherwise stated. Ppa: pulmonary arterial pressure; RV: right ventricle #: estimated pulmonary pressures without adding central venous pressure.