Table 4—

Influence of dog and cat exposure in interaction withCD14 genotypes on total serum immunoglobulin (Ig)E levels at age 4 and 8 yrs

SNP	Genotype	No exposure^#			Dog exposure^¶			Cat exposure⁺			p-value interaction^§
SNP	Genotype	IgE^ƒ	n	p-value	IgE^ƒ	n	p-value	IgE^ƒ	n	p-value	Dog versus no exposure	Cat versus no exposure
Age 4 yrs
3′UTR	CC+CA	30	481	0.33	29	104	0.11	29	177	0.07	0.05^##	0.53
	AA	39	44		11	7		67	13
-159C/T	CC+CT	29	431	0.05^##	31	82	0.14	30	154	0.31	0.01^##	0.59
	TT	40	99		18	28		41	36
-1145T/C	TT+CT	28	429	0.05^##	31	81	0.08	30	154	0.42	0.005^##	0.46
	CC	40	99		17	30		38	38
-1619T/C	TT+CT	29	422	0.13	30	83	0.05^##	31	149	0.67	0.03^##	0.54
	CC	40	69		14	18		36	27
-550C/T	CC	33	279	0.12	19	64	0.003^##	39	109	0.01^##	0.00001^##	0.19
	CT	30	202		39	37		23	74
	TT	18	31		129	6		9	6
Age 8 yrs
3′UTR	CC+CA	73	402	0.35	54	64	0.42	59	155	0.37	0.80	0.38
	AA	55	34		20	2		86	17
-159C/T	CC+CT	65	341	0.03^##	55	52	0.68	59	141	0.24	0.16	0.63
	TT	99	92		44	14		85	32
-1145T/C	TT+CT	65	344	0.05^##	55	51	0.44	57	142	0.14	0.10	0.91
	CC	95	95		38	16		92	31
-1619T/C	TT+CT	70	347	0.36	66	55	0.02^##	57	138	0.17	0.01^##	0.72
	CC	87	62		17	7		92	26
-550C/T	CC	71	248	0.62	31	36	0.30	70	100	0.21	0.03^##	0.27
	CT	72	168		82	24		45	67
	TT	49	19		135	5		46	6

In total, 110 children were exposed to both cat and dog and in these children, similar results were observed. SNP: single nucleotide polymorphism; UTR: untranslated region. ^#: neither cat nor dog exposure; ^¶: exposure to dog, with no cat exposure, at home in the first year of life;⁺: exposure to cat, with no dog exposure; ^§: from linear regression analyses adjusted for sex, maternal atopy, paternal atopy, siblings, breast feeding and environmental tobacco smoke exposure;^ƒ: geometric mean IgE values; ^##: statistically significant.