Distribution of aberrant murine double minute clone 2(MDM2), nucleophosmin (NPM) and p14 alternate reading frame (arf) expression according to histological classification
| Histology | High MDM2 | NPM nucleolar relocalised | p14arf | ||
| Negative | Nucleolar relocalised | Aberrant expression# | |||
| Normal | 5/26 (19) | 0/15 (0) | 4/16 (25) | 0/16 (0) | 4/16 (25) |
| Hyperplasia | 8/36 (22) | 2/22 (9) | 4/26 (15) | 1/26 (4) | 5/26 (19) |
| Metaplasia | 9/32 (28) | 1/22 (5) | 4/24 (17) | 1/24 (4) | 5/24 (21) |
| Mild dysplasia | 16/20 (80)***,¶ | 1/16 (6) | 2/16 (13) | 1/16 (7) | 3/16 (20) |
| Moderate dysplasia | 14/18 (80) | 4/17 (24)¶,+ | 5/18 (29) | 2/18 (11) | 7/18 (40) |
| Severe dysplasia | 15/19 (76) | 4/18 (22) | 9/18 (50)***,¶ | 4/18 (22)***,¶ | 13/18 (72)***,¶ |
| In situ carcinoma | 13/16 (81) | 2/16 (13) | 9/16 (56) | 2/16 (18) | 11/16 (74) |
| Invasive carcinoma | 9/12 (75) | 6/10 (60) | 5/10 (50) | 2/10 (20) | 7/10 (70) |
| Overall | 89/179 (50) | 20/136 (15) | 42/144 (29) | 13/144 (9) | 55/144 (38) |
Data are expressed as number of biopsies with aberrant protein expressed/total number of assessed biopsies (%). #: total of negative and nucleolar localised groups. ¶: stage at which protein expression changed significantly. +: p = 0.001; ***: p<0.001; p-values obtained by Chi-squared test for a linear trend.