Synthetic | Semi-synthetic# | Natural |
Sivelestat | EPI-hNE-4 (inter-α-inhibitor) | α1-antitrypsin |
Midesteine | SUPG-032 (α1-antichymotrypsin) | SLPI |
SLAPI (α1-antitrypsin and SLPI) | Pre-elafin | |
Monocyte/neutrophil elastase inhibitor |
EPI: engineered protein inhibitor; SLAPI: α1-antitrypsin–secretory leukocyte protease inhibitor (SLPI) fusion protein. #: obtained by modification of the natural mother compounds shown in parentheses.