Patient characteristics and lung function data at baseline for all bronchial challenge visits
| Study | ||||||
| 1 | 2 AMP | 3 MCh | ||||
| Age yrs | 25±1 | 26±1 | 28±1 | |||
| Sex M/F n | 7/5 | 7/5 | 5/7 | |||
| First visit | ||||||
| FEV1 L | 3.7±0.2 | 3.5±0.2 | 3.4±0.3 | |||
| FEV1 % pred | 92±4 | 91±4 | 89±4 | |||
| FEV1/FVC | 0.80±0.03 | 0.78±0.02 | 0.77±0.02 | |||
| Rrs cmH2O·L−1·s | 4.5±0.4 | 4.3±0.3 | 3.9±0.4 | |||
| Third or fourth visit | AMP | MCh | Placebo | Salbutamol | Placebo | Salbutamol |
| FEV1 L | 3.2±0.2 | 3.2±0.2 | 3.5±0.2 | 3.5±0.2 | 3.3±0.2 | 3.3±0.2 |
| Rrs cmH2O·L−1·s | 4.6±0.3 | 4.6±0.4 | 4.4±0.4 | 4.3±0.3 | 4.0±0.4 | 3.9±0.4 |
| QT L·min−1 | 5.7±0.3 | 5.6±0.3 | ||||
| V′O2 mL·min−1 | 197±9 | 186±12 | 241±13 | 240±15 | 226±26 | 231±20 |
| Pa,O2 mmHg | 100±2 | 100±2 | 99±2 | 98±1 | 98±2 | 97±3 |
| PA–a,O2 mmHg | 4±1 | 2±1 | 5±2 | 3±1 | 6±2 | 8±2 |
| log SDQ | 0.47±0.04 | 0.44±0.02 | ||||
| log SDV | 0.48±0.03 | 0.45±0.02 | ||||
| DISP R-E* | 3.15±0.49 | 2.38±0.26 | ||||
Data are presented as mean±se, unless otherwise stated. AMP: adenosine 5′-monophosphate; MCh: methacholine; M: male; F: female; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; Rrs: respiratory system resistance; QT: cardiac output; V′O2: oxygen uptake; Pa,O2: arterial oxygen tension; PA–a,O2: alveolar–arterial oxygen tension difference; log SDQ: dispersion of the pulmonary blood flow distribution; log SDV: dispersion of the alveolar ventilation distribution; DISP R-E*: dispersion of retention minus excretion of inert gases corrected for dead space. 1 mmHg = 0.133 kPa.