Table 1—

Baseline patient characteristics shown by sex at the time of entry into the study

Variable	All	Male	Female	p-value^#
Subjects n	1379	1221	158
Age yrs	66±9	66.5±9	62.6±10	<0.0001
Weight kg	78.7±18	80.4±18	65.6±16	<0.0001
Height cm	171.7±9	173±8	159±8	<0.0001
6MWD m	365.9±133	363±135	388±116	<0.02
Enright
m pred	523±71	528±70	488±67	<0.0001
% pred	71.2±27	70±28	79±23	<0.0001
Troosters
m pred	653±66	662±61	582±68	<0.0001
% pred	56.6±21	55±21	66.6±20	<0.0001
6MWD work m·kg⁻¹	28783±1240	29183±1265	25304±9673	<0.0001
Current smoking %	32	31	41	<0.009
Ejection fraction %	55.9±11	55.9±10	57.6±8.7	>0.05
Charlson comorbidity points	4.15±2.7	4.34±2.7	2.7±2.3	<0.0001
FEV₁
L	1.28±0.6	1.30±0.59	1.13±0.46	<0.009
% pred	43.8±18	42.8±17	50.3±20	<0.0001
MMRC dyspnoea scale points	2.3±1	2.32±1.08	2.14±1	<0.044
BMI kg·m⁻²	26.6±5.6	26.7±5.6	25.7±6	<0.049
BODE index points	4.1±2.4	4.2±2.46	3.52±2.24	<0.0004
FVC
L	2.77±1.91	2.85±2	2.19±0.7	<0.0001
% pred	72.7±21	72±20	78.8±23	<0.003
FEV₁/FVC %	46±18	45.9±19	48.8±12	<0.009
IC L	2.04±0.6	2.09±0.69	1.67±0.4	<0.0001
TLC
L	7.14±1.7	7.33±1.6	5.73±1.21	<0.0001
% pred	116±25	116±25	120±22	>0.05
IC/TLC %	0.30±0.1	0.30±0.11	0.30±0.1	>0.05
FRC
L	5.1±1.7	5.24±1.6	4.20±1.3	<0.0001
% pred	147±44	146±44	154±47	>0.05
RV
L	4.4±1.6	4.48±1.6	3.65±1.2	<0.0001
% pred	184±68	184±68	189±67	>0.05
D_L,CO
L	11.5±5.1	11.7±5.1	8.52±3.7	<0.0001
% pred	52±20	53±20	44±16	<0.0001
RV/TLC %	59±12	59.6±12	61±10	>0.05

Data are presented as mean±sd unless otherwise stated. 6MWD: 6-min walk distance; % pred: % predicted; FEV₁: forced expiratory volume in one second; MMRC: Modified Medical Research Council; BMI: body mass index; BODE: Body mass index, Obstruction, Dyspnoea, Exercise capacity; FVC: forced vital capacity; IC: inspiratory capacity; TLC: total lung capacity; FRC: functional residual capacity; RV: residual volume; D_L,CO: diffusing capacity of the lung for carbon monoxide. ^#: p-value between males and females.