Interleukin(IL)-18 immunoreactivities in lungs of chronic obstructive pulmonary disease patients, smokers and nonsmokers
| Subjects n | Age yrs | Total cells·mm−2 | Immunoreactivity IL-18 positive cells·mm−2 (%) | |||
| AMs | IMNCs | AMs | IMNCs | |||
| Nonsmoker | 23 | |||||
| Male | 10 | 66.5±2.9 | 1.3±0.2 | 0.8±0.1 | 0.5±0.1 (34.4±6.4) | 0.1±0.02 (15.0±2.6) |
| Female | 13 | 65.1±1.8 | 1.3±0.1 | 0.7±0.1 | 0.7±0.1 (48.9±6.4) | 0.07±0.01 (9.7±0.9) |
| Smoker | 27 | |||||
| Male | 16 | 67.9±2.0 | 16.5±2.8* | 12.8±2.7* | 7.1±1.3 (42.0±1.3) | 4.2±0.8 (35.0±1.7)* |
| Female | 11 | 60.5±3.1 | 17.0±1.4* | 13.9±0.7* | 6.3±0.6 (37.1±1.8) | 3.9±0.3 (28.0±2.2)* |
| Patient# | ||||||
| 1 | 1 | 71 | 35.1 | 79.3 | 27.0 (77.2) | 43.6 (55.0) |
| 2 | 1 | 48 | 66.3 | 99.3 | 51.7 (78.0) | 51.6 (52.0) |
| 3 | 1 | 66 | 47.4 | 85.4 | 39.9 (84.3) | 46.7 (54.7) |
| 4 | 1 | 76 | 42.4 | 78.4 | 37.8 (89.3) | 43.6 (55.7) |
| 5 | 1 | 67 | 83.0 | 98.9 | 62.2 (75.0) | 49.0 (49.6) |
| 6 | 1 | 72 | 62.3 | 91.7 | 45.5 (73.1) | 48.9 (53.4) |
| 7 | 1 | 65 | 78.9 | 114.1 | 62.2 (78.9) | 65.6 (57.5) |
| 8 | 1 | 72 | 68.2 | 86.0 | 56.8 (83.4) | 46.0 (53.6) |
| 9 | 1 | 53 | 74.7 | 88.1 | 68.4 (91.6) | 44.2 (50.2) |
| 10 | 1 | 56 | 66.0 | 69.3 | 52.5 (79.6) | 32.5 (47.0) |
| 11 | 1 | 78 | 54.3 | 95.0 | 45.5 (83.9) | 44.1 (46.5) |
| 12 | 1 | 71 | 61.2 | 68.0 | 52.8 (86.3) | 29.5 (43.5) |
| 13 | 1 | 67 | 29.8 | 44.6 | 25.8 (86.9) | 22.3 (50.1) |
| 14 | 1 | 73 | 106.8 | 102.4 | 90.0 (84.3) | 50.3 (49.2) |
| 15 | 1 | 62 | 71.8 | 79.6 | 61.3 (85.5) | 36.8 (46.3) |
| 16 | 1 | 72 | 37.0 | 100.0 | 35.5 (96.2) | 50.0 (50.0) |
| Mean | 16 | 66.8±2.0 | 61.5±5.0*,¶ | 86.2±4.1*,¶ | 50.9±4.0 (83.3±1.5)*,¶ | 44.1±2.5 (50.9±0.9)*,¶ |
Data are presented as n, n(%) or mean±sem. IL: interleukin; AM: alveolar macrophage; IMNC: infiltrating mononuclear cell. #: all males. *: p<0.05 versus nonsmokers; ¶: p<0.05 versus smokers.