Peripheral blood mononuclear cell(PBMC) and bronchoalveolar lavage mononuclear cell (BALMC) immunophenotypes in patients with culture-positive tuberculosis (TB) and other pulmonary diseases
| Lymphocyte surface marker | TB group | Non-TB group | ||||
| PBMCs | BALMCs | p-value | PBMCs | BALMCs | p-value | |
| Subjects n | 12 | 12 | 16 | 16 | ||
| CD4 | 38 (26–49) | 52 (20–59) | ns | 32 (21–42) | 37 (20–58) | ns |
| CD8 | 39 (36–51) | 35 (31–67) | ns | 40 (29–48) | 34 (22–54) | ns |
| CD4/CD45RA | 17 (10–25) | 1 (1–3) | 0.012 | 12 (5–25) | 2 (2–4) | 0.001 |
| CD4/CD45R0 | 17 (13–26) | 50 (18–57) | 0.013 | 15 (11–22) | 35 (18–57) | 0.011 |
| CD38 | 55 (43–69) | 35 (26–60) | 0.012 | 50 (40–66) | 34 (24–44) | 0.041 |
| HLA-DR | 33 (24–52) | 48 (41–80) | 0.017 | 33 (24–41) | 59 (37–70) | 0.031 |
| CD19 | 11 (8–17) | 2 (1–5) | 0.005 | 11 (7–24) | 4 (3–6) | 0.027 |
| CD3 | 75 (62–78) | 76 (75–84) | ns | 69 (47–74) | 75 (59–85) | ns |
| CD57 | 34 (17–53) | 22 (19–32) | ns | 33 (20–50) | 32 (23–44) | ns |
| CD16 | 12 (11–20) | 5 (1–8) | 0.007 | 18 (12–31) | 7 (5–14) | 0.008 |
| CD4:CD8 ratio | 0.75 (0.6–1.7) | 1.66 (0.3–1.8) | ns | 0.72 (0.5–1.2) | 1.18 (0.4–2.7) | 0.049 |
Data are presented as median (interquartile range) percentage of cells bearing marker, unless otherwise stated. HLA: human leukocyte antigen; ns: nonsignificant.