Daily | Weekly | p-value | |
Total adverse events | 24/103 | 34/105 | 0.27 |
Gastro-intestinal adverse events# | 9/103 | 27/105 | 0.02 |
Frequency of four-fold increase from baseline in ALT | 4/103 | 1/104 | 0.21 |
Frequency of four-fold increase from baseline in AST | 2/103 | 1/103 | 1.00 |
Data are presented as n/total number of subjects, unless otherwise stated. ALT: alanine aminotransferase; AST: aspartate aminotransferase. #: gastro-intestinal adverse events of diarrhoea, nausea, abdominal symptoms, vomiting, constipation, pancreatitis, anorexia and weight loss; nongastro-intestinal adverse events of thrush, haemoptysis, headache, photosensitivity, rash, ocular surface irritation, dehydration, nightmares, difficulty concentrating, mood swings, hearing muffled, dry skin and hair, and pneumothorax.