Table 6—

Patients admitted, time spent in hospital, number of admissions and time to first exacerbation in study population

	Patients admitted %			Mean days in hospital			Mean number of admissions			Mean days to first exacerbation
	Pre-trial^#	Trial	p-value^¶	Pre-trial^#	Trial	p-value^¶	Pre-trial^#	Trial	p-value^¶	Trial
Daily	62	32	<0.0001	15.5±18.9	6.5±12.1	<0.0001	1.3±1.3	0.6±1.0	<0.0001	70.0±44.8
Weekly	58	41	0.0931	10.7±14.6	6.5±9.6	0.0046	0.8±0.9	0.6±0.8	0.0151	87.3±50.6
p-value⁺	0.66	0.24		0.083	0.28		0.045	0.45		0.17

^#: 6 months immediately prior to study commencement; ^¶: p-values relate to difference within group over time; ⁺: p-values relate to differences between groups (daily versus weekly).