Magnitude of elevations in previously bosentan-naïve patients who experienced aminotransferase elevations
| Magnitude of elevation | Patients# |
| ≤3×ULN | 17 (0.4) |
| >3–≤5×ULN | 130 (2.8) |
| >5–≤8×ULN | 57 (1.2) |
| >8×ULN | 62 (1.3) |
| Unknown | 86 (1.9) |
| Total | 352 (7.6) |
Data are presented as n (%). ULN: upper limit of normal. #: percentage of all patients naïve to bosentan therapy (n = 4,623).