Table 4—

Agreement between various definitions of chronic obstructive pulmonary disease(COPD)

	LLN FEV₁/FVC				LLN FEV₁/SVC post-bronchodilator^#		Doctor diagnosis
	Post-bronchodilator		Pre-bronchodilator		LLN FEV₁/SVC post-bronchodilator^#		Doctor diagnosis
	Yes	No	Yes	No	Yes	No	Yes	No
GOLD
Yes	75	41	88	28	70	44	17	99
No	3	630	32	601	3	629	62	571
Kappa (95% CI)	0.74 (0.67–0.81)		0.70 (0.63–0.80)		0.71 (0.64–0.79)		0.06 (-0.02–0.13)
LLN FEV₁/FVC post- bronchodilator
Yes			72	6	68	10	15	63
No			48	623	5	663	64	607
Kappa (95% CI)			0.69 (0.61–0.76)		0.89 (0.83–0.94)		0.09 (0.007–0.18)
LLN FEV₁/FVC pre- bronchodilator
Yes					67	51	21	99
No					6	622	58	571
Kappa (95% CI)					0.66 (0.58–0.74)		0.09 (0.01–0.18)
LLN FEV₁/SVC post- bronchodilator
Yes							14	59
No							65	608
Kappa (95% CI)							0.09 (0.003–0.18)

LLN: lower limit of normal; FEV₁: forced expiratory volume in one second; FVC: forced vital capacity; SVC: slow vital capacity; GOLD: Global Initiative for Chronic Obstructive Lung Disease; CI: confidence interval. ^#: three subjects had missing data for SVC.