Vastus lateralis biopsy | Tibialis anterior biopsy | |||
Controls | COPD | Controls | COPD | |
Subjects n | 4 | 6 | 6 | 6 |
Male/female n | 3/1 | 4/2 | 6/0 | 6/0 |
Age yrs | 60.5±3.1 | 60.0±11.8 | 65.2±6.6 | 66.5±9.6 |
Length m | 1.71±0.05 | 1.69±0.06 | 1.79±0.04 | 1.75±0.06 |
Weight kg | 80.8±8.3 | 75.8±18.7 | 84.3±5.0 | 66.0±10.7# |
BMI kg·m−2 | 27.5±1.6 | 26.5±5.7 | 26.3±2.0 | 21.5±3.5* |
FFM kg | 61.0±8.6 | 53.5±6.8 | 81.7±3.6 | 53.5±6.0# |
FFMI kg·m−2 | 20.7±2.0 | 18.3±2.5 | 25.5±1.3 | 17.6±3.0# |
FEV1 % pred | 99.5±11.4 | 53.7±22.9* | 111.7±10.6 | 35.4±11.6# |
FVC % pred | 109.3±13.3 | 88.7±21.3 | 117.3±2.0 | 84.6±19.5# |
FEV1/FVC % | 73.3±0.9 | 47.7±13.8* | 73.0±8.9 | 32.8±8.7# |
DL,CO % pred | 114.0±11.7 | 86.1±19.3* | 123.4±20.8 | 65.8±39.6* |
Smoking habits n | ||||
Smoker | 0 | 0 | 1 | 1 |
Nonsmoker | 0 | 0 | 2 | 1 |
Ex-smoker | 4 | 6 | 3 | 4 |
Data are presented as mean±sd, unless otherwise stated. COPD: chronic obstructive pulmonary disease; BMI: body mass index; FFM: fat-free mass; FFMI: FFM index; FEV1: forced expiratory volume in one second; % pred: % predicted; FVC: forced vital capacity; DL,CO: diffusing capacity of the lung for carbon monoxide. *: p<0.05 compared with controls; #: p≤0.01 compared with controls.