Table 2—

Clinical profiles of four patients who died after developing drug-induced hepatitis

SexAge yrsOnset of hepatitis weeksHBsAgHCVAbDrinking historyPredominant hepatotoxic drugs#SymptomsALT U·L−1Bilirulin µmol·L−1
Male+696+NANAH, R, ZNA149Normal
Female918.4NANANAH, RNA2755
Male6717.3+NANAH, R, ZTiredness76173
Male7527NANANAH, RNo750162
  • HBsAg: hepatitis B surface antigen; HCVAb: hepatitis C antibody; ALT: alanine aminotransferase; NA: not available; H: isoniazid; R: rifampicin; Z: pyrazinamide. #: within the previous 4 weeks; : at the time of diagnosis; +: overdosed with pyrazinamide 3,500 mg·day−1.