Lung function test results
| Placebo | Irbesartan | p-value# | |||
| Baseline | 4 months | Baseline | 4 months | ||
| PI,max kPa | 5.5±2.0 | 5.8±2.2 | 4.8±1.9 | 4.5±2.0 | 0.16 |
| P0.1,max kPa | 3.3±1.0 | 3.4±1.7 | 2.9±1.0 | 2.7±1.3 | 0.47 |
| FEV1/vital capacity % | 42±12 | 38±11 | 40±7 | 43±13 | 0.07 |
| Vital capacity L | 2.3±0.7 | 2.5±1.0 | 2.3±0.7 | 2.1±0.7 | 0.18 |
| FEV1 L·s−1 | 0.95±0.3 | 0.95±0.6 | 0.91±0.3 | 0.87±0.3 | 0.67 |
| Raw,tot kPa·L−1·s | 0.79±0.59 | 0.64±0.4 | 0.67±0.4 | 0.69±0.5 | 0.14 |
| Total lung capacity % pred | 110.4±23 | 121.7±25.8* | 119.7±16 | 113.7±19.2 | 0.01 |
| Residual volume/total lung capacity % | 66.2±11.0 | 70.4±10.3* | 68.9±7.2 | 68.8±7.3 | 0.08 |
| Pa,O2mmHg | 64.4±10.4 | 62.5±11.8 | 65.7±10.4 | 66.7±12 | 0.31 |
| Pa,CO2 mmHg | 43.3±3.4 | 44.3±3.7 | 42.9±3.6 | 42.8±3.5 | 0.45 |
| Quadriceps maximal muscle strength N | 22.1±9.1 | 22.3±9.8 | 19.6±8.6 | 21.6±9.3 | 0.18 |
| Weight kg | 76.0±15.1 | 76.1±16.8 | 71.3±14.9 | 72.2±14.8 | 0.51 |
Data are presented as mean±sd. PI,max: maximal inspiratory pressure; P0.1,max: maximal mouth occlusion pressure at 0.1 s; FEV1: forced expiratory volume in one second; Raw,tot: total airway resistance; % pred: percentage of the predicted value; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension. For details of correction for multiple comparisons, see Statistical analysis. #: ANOVA for time by treatment interaction. *: p<0.05 (ANOVA for time). 1 mmHg = 0.133 kPa.