Outcome parameters in mild-to-moderate and severe asthma
| Mild-to-moderate asthma | Severe asthma | p-value | |
| Subjects n | 17 | 14 | |
| Alveolar NO# ppb | 0.3 (-1.4–3.9) | 1.9 (-2.8–9.6) | 0.11 |
| Bronchial NO# nL·s−1 | 1.9 (0.8–4.3) | 2.1 (0.1–5.8) | 0.94 |
| FRC % pred | 118.8±22.8 | 101.8±25.2 | 0.06 |
| TLC % pred | 104.0±11.6 | 94.9±8.0 | 0.02 |
| RV/TLC % pred | 105.5±25.9 | 113.4±18.2 | 0.35 |
| dN2 %·L-1 | 0.8 (0.3–2.1) | 1.6 (0.5–9.1) | 0.02 |
| CC/TLC L | 39.7±6.3 | 46.8±12.0 | 0.06 |
| ΔFVC % | 10.8 (4.0–19.1) | 13.5 (11.4–21.8) | 0.03 |
Data are presented as mean±sd or median (range), unless otherwise stated. #: Alveolar nitric oxide (NO) and bronchial NO were measured in 16 patients with mild-to-moderate and 10 patients with severe asthma. FRC: functional residual capacity; % pred: per cent predicted; TLC: total lung capacity; RV: residual volume; dN2: slope of the single breath nitrogen washout curve; CC: closing capacity; ΔFVC: percentage fall in forced vital capacity at the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second.