Post-operative haemodynamics and pulmonary capillary permeability and gas exchange
| Cardiac surgery | Vascular surgery | |||
| Statin | No statin | Statin | No statin | |
| Subjects n | 25 | 12 | 12 | 15 |
| Haemodynamics | ||||
| Cardiac frequency beats·min−1 | 71 (55–101) | 78 (60–88) | 71 (63–87) | 70 (46–98) |
| Ppcw mmHg | 7 (1–13) (n = 17) | 7 (3–10) (n = 5) | 7 (6–10) (n = 5) | 6 (4–7) (n = 6) |
| P̄pa mmHg | 15 (8–28) | 15 (10–21) | 19 (13–24) | 16 (12–17) |
| MAP mmHg | 73 (52–104) | 77 (63–96) | 72 (63–107) | 82 (55–113) |
| CI L·min−1·m−2 | 3.1 (2.1–4.8) | 2.9 (2.2–3.9) | 3.0 (1.6–4.7) | 3.1 (2.2–4.5) |
| GEDVI mL·m−2 | 839 (537–1108) (n = 20) | 833 (584–1180) (n = 10) | 903 (547–1149) (n = 7) | 957 (629–1563) (n = 13) |
| GEF % | 23 (11–29) | 19 (11–27) | 20 (14–32) | 20 (7–41) |
| Respiratory variables | ||||
| PLI 10−3·min−1 | 15 (6–73) | 16 (7–53) | 23 (6–73) | 19 (10–101) |
| Supranormal# PLI | 13 (52) | 6 (50) | 8 (67) | 10 (67) |
| EVLW mL·kg−1 | 6.1 (2.1–13.2) (n = 20) | 6.8 (2.9–20.0) (n = 10) | 7.2 (5.2–13.8) (n = 7) | 5.9 (2.5–46.8) (n = 13) |
| Pa,O2 mmHg | 116 (84–181) | 126 (88–185) | 123 (76–178) | 130 (70–220) |
| FI,O2 % | 41 (37–62) | 40 (39–50) | 48 (39–60) | 41 (39–58) |
| Pa,O2/FI,O2 mmHg | 270 (140–454) | 298 (176–472) | 264 (127–445) | 289 (121–537) |
| Qs/Qt % | 17 (9–62) | 14 (9–20) | 22 (9–40) | 20 (4–45) |
| PEEP cmH2O | 7 (4–16) | 7 (5–12) | 7 (5–10) | 6 (5–10) |
| Plateau pressure cmH2O | 17 (13–33) | 18 (14–24) | 20 (12–23) | 19 (14–24) |
| Tidal volume mL | 571 (400–1110) | 514 (395–690) | 645 (430–710) | 600 (450–730) |
| Total dynamic compliance mL·cmH2O−1 | 51 (37–91) | 49 (39–67) | 53 (31–94) | 49 (28–91) |
| Radiographic quadrants with opacities | 0 (0–3) | 0 (0–2) | 2 (0–3) | 1 (0–3) |
| Lung injury score¶ | 0.8 (0.3–2.8) | 0.9 (0.3–1.8) | 1.5 (0.3–2.0) | 1.0 (0.3–2.0) |
| Duration of mechanical ventilation h | 13 (6–494) | 9 (5–316) | 18 (7–1992) | 14 (1–457) |
Data are presented as median (range) or n (%) as appropriate, unless otherwise stated. Ppcw: pulmonary capillary wedge pressure; P̄pa: mean pulmonary arterial pressure; MAP: mean arterial pressure; CI: cardiac index; GEDVI: global end-diastolic volume index; GEF: global ejection fraction; PLI: pulmonary leak index; EVLW: extravascular lung water; Pa,O2: arterial oxygen tension; FI,O2: inspiratory oxygen fraction; Qs/Qt: venous admixture; PEEP: positive end-expiratory pressure. #: >14.7×10−3·min−1; ¶: Murray lung injury score, based on plain chest radiograph findings, oxygenation, minute ventilation, lung compliance and PEEP.