Genotyping and association results of chronic obstructive pulmonary disease under a codominant model
| Gene | Common name | Controls | Cases | OR | Adjusted OR | |||||||||||||
| n | MAF | Genotypes % | p-value# | n | MAF | Genotypes % | Het OR | Hom OR | p-value¶ | Het OR | Hom OR | p-value+ | ||||||
| 1–1 | 1–2 | 2–2 | 1–1 | 1–2 | 2–2 | |||||||||||||
| EPHX1 | Tyr113His | 241 | 0.31 | 50 | 39 | 11 | 0.29 | 239 | 0.30 | 46 | 49 | 5 | 1.34 | 0.50 | 0.02 | 1.26 | 0.51 | 0.06 |
| His139Arg | 246 | 0.22 | 61 | 35 | 5 | 0.85 | 238 | 0.22 | 61 | 35 | 4 | 1.01 | 0.94 | 1.00 | 1.01 | 0.89 | 0.97 | |
| TNF | −308 G>A | 244 | 0.20 | 65 | 30 | 5 | 0.42 | 240 | 0.20 | 64 | 31 | 5 | 1.04 | 0.94 | 0.99 | 0.93 | 1.09 | 0.91 |
| −376 G>A | 245 | 0.01 | 98 | 2 | 0 | 1.00 | 242 | 0.01 | 98 | 2 | 0 | 0.81 | NA | 0.87 | 1.21 | NA | 0.78 | |
| −238 G>A | 244 | 0.04 | 92 | 8 | 0 | 1.00 | 242 | 0.05 | 90 | 10 | 0 | 1.25 | NA | 0.47 | 1.57 | NA | 0.19 | |
| ADRB2 | Gln27Glu | 245 | 0.47 | 27 | 53 | 20 | 0.44 | 244 | 0.45 | 29 | 54 | 18 | 0.96 | 0.81 | 0.73 | 1.06 | 0.86 | 0.71 |
| Gly16Arg | 239 | 0.40 | 38 | 46 | 17 | 0.50 | 238 | 0.41 | 33 | 51 | 16 | 1.26 | 1.08 | 0.50 | 1.32 | 0.99 | 0.34 | |
OR: odds ratio; MAF: minor allele fraction; Het OR: heterozygote OR; Hom OR: OR homozygote for minor allele; EPHX1: microsomal epoxide hydroxylase; TNF: tumour necrosis factor; ADRB2: β2-adrenoreceptor; NA: not applicable or computable, due to a sparse 2×2 table. #: p-value from test for Hardy–Weinberg equilibrium in controls; ¶: p-values from Fisher's exact test; +: p-values from logistic regression, adjusted for age, pack-yrs and sex.