SubjectNo. | Age yrs | Sex | Heightcm | Asthma drug | Steroidµg·day−1 | Baseline FEV1% pred | Mannitol | ||
Total dose#mg | PD15mg | Reduction in FEV1¶% | |||||||
1 | 30 | M | 184 | TS, B, FF | 400 | 99.1 | 475 | 170.3 | 34.6 |
2 | 30 | M | 178 | S | 83.1 | 635 | 151.6 | 25.2 | |
3 | 32 | M | 172 | S | 88.7 | 155 | 88.1 | 31.3 | |
4 | 30 | F | 169 | S | 115.5 | 155 | 61.4 | 34.0 | |
5 | 25 | M | 173 | S, FP | 2000 | 81.0 | 635 | 342.5 | 31.5 |
6 | 20 | F | 167 | TS | 94.1 | 155 | 85.9 | 25.7 | |
7 | 28 | F | 181 | S | 69.9 | 75 | 15.2 | 38.7 | |
8 | 31 | M | 175 | S | 79.1 | 155 | 88.8 | 26.1 | |
9 | 17 | F | 170 | S | 115.8 | 75 | 40.5 | 27.2 | |
10 | 31 | M | 185 | S, FP/SX | 500 | 93.5 | 475 | 260.9 | 25.7 |
11 | 19 | F | 169 | S, FP/SX | 50 | 89.2 | 75 | 41.1 | 27.2 |
12 | 22 | F | 173 | S, FP | 250 | 93.7 | 315 | 174.4 | 27.2 |
13 | 25 | F | 166 | S | 84.0 | 75 | 42.2 | 27.9 | |
14 | 37 | F | 165 | S | 85.6 | 75 | 30.5 | 25.3 | |
Mean±sd | 91±13 | 252±213 | 81 (49–135)+ | 29±4 |
FEV1: forced expiratory volume in one second; PD15: provocative dose of mannitol causing a 15% fall in FEV1; M: male; F: female; TS: terbutaline sulphate; B; budesonide; FF: formoterol fumarate; S: salbutamol; FP: fluticasone propionate; SX: salmeterol xinafoate; FP/SX: FP and SX in combination. #: giving rise to ≥25% fall in FEV1; ¶: maximum on control day; +: geometric mean (95% confidence interval).