Oxygen % | Threshold | 200 mg threshold | End of experiment |
Control | |||
1.5 | 58.1±16.8 | 53.6±21.1 | 57.3±22.1* |
3.0 | 46.9±15.4 | 47.3±15.3 | 53.5±17.7* |
6.0 | 56.9±14.2 | 65.8±9.5 | 113.5±37.0# |
14.5 | 72.2±10.5 | 85.0±14.5 | 162.5±32.0# |
35.0 | 60.9±7.1 | 72.6±28.3 | 145.5±13.6# |
Terbutaline treated lungs | |||
1.5 | 41.0±7.5 | 37.2±12.0 | 40.5±7.9* |
3.0 | 32.4±3.7 | 34.0±9.3 | 54.7±16.0* |
6.0 | 60.9±9.8 | 60.0±7.8 | 84.1±31.7#,+ |
14.5 | 62.3±10.9 | 68.0±9.4 | 101.2±16.5# |
35.0 | 53.9±9.8 | 60.5±6.9 | 120.3±43.4# |
Data are presented as mean±sd. LDH activity was measured in aliquots of perfusate during the long-term experiments. Threshold LDH activity was extrapolated to the time when the weight gained was 200 mg. End of experiment samples were taken at the termination of experiments. Data were obtained from 5–8 experiments. *: difference to 35% O2, p<0.05; #: difference to begin of experiment, p<0.05; +: difference between control and terbutaline treated lungs, p<0.05.