Tiotropium | Placebo | p-value | |
All severities | |||
Patients with one or more exacerbations % | 49.9 | 60.3 | <0.01 |
Exacerbations per patient per yr | 1.57 | 2.41 | <0.001 |
Moderate-to-severe | |||
Patients with one or more exacerbations % | 42.5 | 53.4 | <0.001 |
Number of exacerbations per patient per yr | 1.10 | 1.69 | <0.001 |
Mild | |||
Patients with one or more exacerbations % | 13.1 | 15.6 | ns |
Number of exacerbations per patient per yr | 0.47 | 0.72 | ns |
ns: nonsignificant.