Genomic actions | Nongenomic actions | ||||
Receptor location | Cytoplasm | Cytoplasm | Membrane | Nonspecific | |
Action's onset and reversibility | Hours–days | Seconds–minutes | |||
Sensitivity to inhibitors of transcription (actinomycin D) and protein synthesis (cycloheximide) | Inhibition | No effect | |||
Activity of membrane impermeant carrier (bovine serum albumin)-coupled drug | Inactive | Inactive | Active | Active |