Table 1—

Genomic and nongenomic actions of corticosteroids

Genomic actionsNongenomic actions
Receptor locationCytoplasmCytoplasmMembraneNonspecific
Action's onset and reversibilityHours–daysSeconds–minutes
Sensitivity to inhibitors of transcription (actinomycin D) and protein synthesis (cycloheximide)InhibitionNo effect
Activity of membrane impermeant carrier (bovine serum albumin)-coupled drugInactiveInactiveActiveActive