Preferred¶ | Alternative+ |
Penicillin G±macrolideƒ | Levofloxacin§ |
Aminopenicillin±macrolide§,ƒ | Moxifloxacin§,## |
Aminopenicillin/β-lactamase inhibitor±macrolide§,ƒ | |
Nonantipseudomonal cephalosporin IIƒ or III±macrolideƒ |
#: experience with ketolides is limited, but they may offer an alternative when oral treatment is adequate; ¶: in regions with low resistance rates; +: in regions with increased resistance rates or intolerance to preferred drugs; §: can be applied as sequential treatment using the same drug; ƒ: new macrolides preferred to erythromycin; ##: within the fluoroquinolones, moxifloxacin has the highest anti-pneumococcal activity.