All weeks of illness | Influenza-positive weeks | |||||
Vaccine | Placebo | p-value | Vaccine | Placebo | p-value | |
Outcomes n | 176 | 166 | 22 | 20 | ||
Upper respiratory tract | ||||||
Runny or stuffy nose | 0.91 | 0.85 | 0.43 | 0.97 | 0.85 | 0.60 |
Sneezing | 0.33 | 0.29 | 0.44 | 0.44 | 0.38 | 0.60 |
Burning or watery eyes | 0.13 | 0.15 | 0.74 | 0.26 | 0.20 | 0.68 |
Sore throat | 0.38 | 0.35 | 0.52 | 0.32 | 0.45 | 0.24 |
Hoarseness | 0.12 | 0.12 | 0.98 | 0.06 | 0.15 | 0.21 |
Fever or shivering | 0.22 | 0.21 | 0.86 | 0.41 | 0.43 | 0.82 |
Headache | 0.39 | 0.33 | 0.30 | 0.37 | 0.54 | 0.27 |
Myalgia | 0.07 | 0.07 | 0.89 | 0.07 | 0.10 | 0.67 |
Total symptom score | 2.56 | 2.37 | 0.37 | 2.91 | 3.13 | 0.69 |
Lower respiratory tract | ||||||
Cough during the day | 0.93 | 1.03 | 0.26 | 1.05 | 1.27 | 0.39 |
Cough during the night | 0.50 | 0.52 | 0.78 | 0.67 | 0.71 | 0.86 |
Wheeze during the day | 0.13 | 0.16 | 0.50 | 0.15 | 0.18 | 0.77 |
Wheeze during the night | 0.10 | 0.11 | 0.58 | 0.07 | 0.11 | 0.50 |
Difficult breathing or shortness of breath | 0.39 | 0.42 | 0.56 | 0.32 | 0.64 | 0.06 |
Total symptom score | 2.05 | 2.24 | 0.33 | 2.25 | 2.91 | 0.24 |
Each separate score ranged from 0 (absent) to 3 (severe).