QoL scores# | All weeks of illness | Influenza-positive weeks | ||||
Vaccine | Placebo | p-value | Vaccine | Placebo | p-value | |
Scores n | 173 | 160 | 21 | 19 | ||
Mean | ||||||
Total | 5.54 | 5.43 | 0.35 | 5.87 | 5.47 | 0.15 |
Activities | 4.85 | 4.73 | 0.38 | 5.23 | 4.82 | 0.27 |
Emotions | 6.30 | 6.26 | 0.28 | 6.47 | 6.38 | 0.75 |
Symptoms | 5.24 | 5.10 | 0.72 | 5.69 | 5.03 | 0.08 |
Mean differences between baseline¶ | ||||||
Total | −0.65 | −0.76 | 0.19 | −0.40 | −1.00 | 0.02 |
Activities | −0.82 | −1.00 | 0.14 | −0.49 | −1.31 | 0.02 |
Emotions | −0.35 | −0.40 | 0.56 | −0.21 | −0.41 | 0.29 |
Symptoms | −0.81 | −0.95 | 0.20 | −0.52 | −1.35 | 0.04 |
MID between baseline+ | ||||||
Total % | 50 | 61 | 0.06 | 48 | 68 | 0.22 |
Activities % | 54 | 64 | 0.06 | 48 | 79 | 0.06 |
Emotions % | 27 | 26 | 1.00 | 24 | 26 | 1.00 |
Symptoms % | 52 | 65 | 0.01 | 43 | 79 | 0.03 |
MID: minimal important difference. #: scores range 1–7, with higher scores indicating better QoL; ¶: negative differences, indicating a poorer QoL during weeks of illness; +: proportion of patients with a negative difference of ≥0.5 points