3 Changes in exhaled nitric oxide(ΔeNO) concentration and demographic data in individual responder groups and their various subgroups with respect to latex sensitisation
| Asthma# | Rhinitis alone | Nonresponders | |||
| Sensitised | Nonsensitised | Sensitised | Nonsensitised | ||
| Subjects n | 13 | 16 | 4 | 2 | 10 |
| ΔeNO ppb | |||||
| 20 min after placebo | 0.1±0.3 | 0.1±0.5 | 0.6±0.9 | 0.4±0.4 | 0.8±0.4 |
| 20 min after latex | 0.5±1.0 | 3.1±1.5 | 3.2±0.7 | 0.1±0.9 | 2.7±0.8 |
| 1 h after latex | 3.2±1.4 | 3.3±1.3 | 7.2±1.3 | 1.4±1.2 | 2.7±0.5 |
| 22 h after latex | 6.2±1.7* | 7.8±3.0 | 1.7±2.0 | 2.4±0.0 | 0.5±0.3 |
| ΔeNO of >50% 22 h after latex | 9 (69)* | 6 (38) | 1 (25) | 0 (0) | 0 (0) |
| Duration yrs | |||||
| Latex glove exposure¶ | 13.3±2.4 | 11.3±2.5 | 5.0±3.0 | 6.5±1.5 | 10.3±2.3 |
| Latex-induced symptoms+ | 4.7±1.1 | 3.3±0.9 | 3.1±1.5 | 3.0±0.5 | 6.8±2.0 |
| Atopy | 8 (62) | 7 (44) | 0 (0) | 1 (50) | 3 (30) |
| Total IgE kU·L−1 | 425±167 | 312±123** | 35±21 | 815±760 | 269±163 |
| Latex-specific IgE kU·L−1 | 9.9±3.5 | 3.4±1.3 | 0.35 | 11.1±9.0 | 0.35 |
| BHR | 10 (77)* | 6 (38) | 1 (25) | 1 (50) | 3 (30) |
Data are presented as mean±sem or n (%). Ig: immunoglobulin; BHR: bronchial hyperresponsiveness. #: all sensitised; ¶: occupational allergenic; +: allergic. *: significantly different from corresponding reference subgroup (nonsensitised nonresponders for asthma group); **: significantly different from corresponding reference subgroup (nonsensitised rhinitis only responders; p<0.05).