2 Change in exhaled nitric oxide(ΔeNO) concentration following placebo and latex allergen challenge in whole study group and various subgroups
| All | Latex sensitisation | On corticosteroids | Latex challenge response | |||||
| Yes | No | Yes | No | Asthma | Rhinitis alone | None | ||
| Subjects n | ||||||||
| All | 45 | 31 | 14 | 9 | 36 | 13# | 20¶ | 12+ |
| Nonsmokers | 28 | 19 | 9 | 6 | 22 | 5 | 15 | 8 |
| Smokers | 17 | 12 | 5 | 3 | 14 | 8 | 5 | 4 |
| ΔeNO ppb | ||||||||
| 20 min after placebo | 0.2±0.3 | 0.1±0.3 | 0.8±0.4 | 0.3±0.4 | 0.1±0.3 | 0.1±0.3 | 0.2±0.4 | 0.8±0.3 |
| 20 min after latex | 2.2±0.6 | 1.8±0.9 | 2.8±0.6 | 1.4±0.9 | 2.3±0.8 | 0.5±1.0 | 3.1±0.9 | 2.2±0.7 |
| 1 h after latex | 3.4±0.6 | 3.1±0.8 | 4.0±0.8 | 4.0±1.4 | 3.2±0.7 | 3.2±1.4 | 4.1±1.1 | 2.4±0.5 |
| 22 h after latex | ||||||||
| All | 4.9±1.3 | 6.8±1.7* | 0.9±0.6 | 1.7±1.4 | 5.7±1.5 | 6.2±1.7 | 6.6±2.3 | 0.8±0.3 |
| Nonsmokers | 5.7±1.7 | 7.8±2.4 | 1.1±0.9 | 1.3±1.9 | 6.9±2.1 | 11.1±2.7 | 6.3±2.8 | 1.2±0.4 |
| Smokers | 3.7±1.8 | 5.1±2.5 | 0.5±0.5 | 2.7±1.8 | 4.0±2.2 | 3.2±1.2 | 7.6±6.1 | 0.1±0.5 |
| ΔeNO of >50% 22 h after latex | ||||||||
| All | 16 (36) | 15 (48)* | 1 (7) | 2 (22) | 14 (39) | 9 (69)* | 7 (35)* | 0 (0) |
| Nonsmokers | 10 (36) | 9 (47) | 1 (11) | 1 (17) | 9 (41) | 5 (100) | 5 (33) | 0 (0) |
| Smokers | 6 (35) | 6 (50) | 0 (0) | 1 (33) | 5 (36) | 4 (50) | 2 (40) | 0 (0) |
Data are presented as mean±sem or n (%). #: all latex sensitised; ¶: 16 latex sensitised and four nonsensitised; +: two latex sensitised and 10 nonsensitised. *: significantly different from corresponding reference subgroup(s).