Table 4—

Kaplan-Meier survival estimates for diagnostic delay and type of presentation

VariableCategorisationSurvival# median (95% CI)p-value
Referral delay+≥243.43 (37.83–49.02)<0.01
>231.86 (28.07–35.65)
Alarm symptoms
 No symptomYes66.43 (51.96–80.90)<0.001
(casual discovery)No33.14 (30.03–36.25)
 CoughYes38.86 (30.79–46.92)<0.05
No35.86 (32.19–39.53)
 Bloody sputumYes46.43 (34.47–58.39)ns
No34.86 (31.58–38.14)
 DyspnoeaYes26.71 (14.06–39.37)<0.01
No37.57 (33.76–41.39)
 Chest painYes27.86 (21.43–34.28)<0.01
No39.29 (35.48–43.09)
 Chest infectionYes49.71 (42.65–56.78)<0.01
No35.14 (31.89–38.40)
 Systemic symptomsYes17.86 (10.82–24.90)<0.001
No38.86 (35.40–42.31)
 Symptoms ofYes24.14 (19.59–28.69)<0.001
local or distant disseminationNo38.86 (35.29–42.43)
  • CI: confidence interval; ns: nonsignificant. #: weeks; : log rank test; +: months from the first symptom of lung cancer (alarming symptom) to the specialist referral (fig. 4)