Potential targets for antitussive drugs
| Cerebral cortex |
| Placebo effect |
| Brainstem |
| Opioid receptors |
| ORL1 receptors |
| GABA-B (and A?) receptors |
| Glycine receptors |
| Tachykinin receptors |
| 5-HT receptors |
| Glutamate receptors |
| Peripheral sensory nerve endings antagonists |
| Vanilloid receptors (VRL1, TRPV1) |
| BK and BKca receptors |
| Neurokinin receptors |
| Opioid receptors |
| ORL1 receptors |
| Na+ channel receptors (TTX-sensitive, insensitive) e.g. local anaesthetics |
| Purine receptors |
| Acid-sensing ion channels |
| Inflammatory and immunological mediators |
| Peripheral sensory endings agonists |
| K+ channels |
| GABA-B receptors |
ORL1: Opioid receptor-like 1 receptors
GABA: gamma aminobutyric acid
5-HT: 5-hydroxytryptamine
VRL1: vanilloid receptor like-1 receptor
TRPV1: Transient receptor potential vanilloid
BK: bradykinin
BKCa: large conductance calcium-activated potassium channel
TTX: tetrodotoxin